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Promethazine Syrup

Promethazine syrup is a commonly used anti-allergy medication. The active ingredient is promethazine, which is a phenothiazine derivative. It is an anti-histamine, which means that it blocks the effects of histamine in the body, which is responsible for the symptoms we see in allergic reactions.

This action is the reason that Promethazine syrup is used for treating symptoms like itching, rashes, sneezing, running nose, watering eyes. Its anti-histamine action also adds a sedative effect.

Another use for Promethazine syrup is for nausea, vomiting and as a mild analgesic. It can also be used for motion sickness.

The dosage of Promethazine Syrup depends upon the age of the patient and the reason for prescribing it. Caution: It should not be used in children below two years of age.

Contra-indications with Promethazine Syrup

Some clinical conditions may interact with promethazine syrup. Tell your doctor or pharmacologist if you have any medical conditions, particularly if any of the following apply to you:

  • if you regularly consume big quantities of alcohol.
  • if you have allergic reactions to medicines, foods, or other elements.
  • if you are pregnant, preparing to become pregnant, or are breast-feeding.
  • if you are taking any prescription or nonprescription medication, natural preparation, or nutritional supplement.
  • if you have a history of nervous system problems, bone marrow depression, heart problems, a blood disease, glaucoma, increased eye pressure, low blood pressure, liver problems, stomach problems (eg, ulcer), a blockage of your bladder or bowel, an enlarged prostate, Parkinson disease, seizures, or Reye syndrome


Side effects of Promethazine Syrup

Common side effects of Promethazine Syrup include drowsiness, dizziness, fatigue, nervousness, hallucinations, dry mouth, and nausea.

Also reported: abnormally fast breathing, palpitations, irregular pulse, abnormal blood pressure, sweating, paleness, weakness or fatigue.

Rare adverse effects include: seizures, muscle stiffness and rigors, abdominal pain, chest pain with irregular pounding heart beat or pulses, confusion, disorientation, bleeding- nose bleeds, heavier periods, blood in urine or stools, double vision or blurred vision, outbreak of hives on face, hands, legs, etc., hallucinations, delusions, excessive sleepiness, night terrors, automatism.

These side effects may be seen in people who have taken large doses in accidental or intentional overdose. In people who have just started the medication, the intensity of the side effects lessens with time. In overdose situations, immediate management is essential to prevent long term damage and toxicity to multiple organ systems.

Symptoms of overdose include:

  • very low blood pressure, dizziness, lightheadedness.
  • depression, irritability, mood changes
  • overactive reflexes, muscle tension, trembling
  • dilated or fixed pupils, not responsive to light
  • unconsciousness
  • sudden death may occur.

Promethazine syrup has interactions with many commonly given medications, and should be used with caution. Some of these include:

  • Acetaminophen,
  • Aspirin,
  • Amiodarone,
  • Citalopram,
  • Dextromethorphan,
  • Gatifloxacin,
  • Haloperidol,
  • Methadone,
  • Metoclopramide,
  • Mifepristone,
  • Procainamide,
  • Propoxyphene,
  • Quinidine,
  • Tramadol

Caution: Promethazone syrup should also not be used with alcohol.

All prescription drugs should be taken with caution after all alternatives have been exhausted. If side affects occur, one should consider discontinuing and using an alternative product. Always consult your primary physician before making major changes to your dosage or schedule.

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